Janet Lovett

Janet Eleanor Lovett

Postal address:
School of Physics & Astronomy
Physical Science Building
North Haugh
St Andrews
United Kingdom

E-mail: [email protected]

Direct phone: +44 (0)1334 463120

 http://orcid.org/0000-0002-3561-450X

Research overview

Measuring nanometre distances for structural biology using EPR spectroscopy.

I use Electron Paramagnetic Resonance (EPR) spectroscopy to measure nanometre distances in proteins and nucleic acids. This provides detail on their structure and dynamics. The methodology is applied to a range of proteins including those for protein excretion in the cell. I am also interested in developing the methods for tagging proteins and nucleic acids to make them suitable for this kind of investigation, as well as advancing the EPR experiments themselves.

The biological preparation and EPR facilities at St Andrews are outstanding with, among others, pulsed and CW X-band, high power Q-band and the home-built high power W-band (HiPER).

Recent Publications

Gil-Ramírez, G, Shah, A, El Mkami, H, Porfyrakis, K, Briggs, AD, Morton, JJL, Anderson, HL & Lovett, JE 2018, ‘Distance measurement of a non-covalently bound Y@C82 Pair with double electron electron resonance spectroscopy’ Journal of the American Chemical Society, vol Just Accepted. DOI: 10.1021/jacs.8b03889\n

Bowen, AM, Johnson, EOD, Mercuri, F, Hoskins, NJ, Qiao, R, McCullagh, JSO, Lovett, JE, Bell, SG, Zhou, W, Timmel, CR, Wong, LL & Harmer, JR 2018, ‘A structural model of a P450-ferredoxin complex from orientation-selective double electron-electron resonance spectroscopy’ Journal of the American Chemical Society, vol 140, no. 7, pp. 2514-2527. DOI: 10.1021/jacs.7b11056\n

Haugland, M, Lovett, JE & Anderson, E 2018, ‘Advances in the synthesis of nitroxide radicals for use in biomolecule spin labelling’ Chemical Society Reviews, vol 47, no. 3, pp. 668-680. DOI: 10.1039/C6CS00550K\n

Drummond, N, Davies, N, Lovett, JE, Miller, M, Cook, G, Becker, T, Becker, C, McPhail, D & Kunath, T 2017, ‘A synthetic cell permeable antioxidant protects neurons against acute oxidative stress’ Scientific Reports, vol 7, 11857. DOI: 10.1038/s41598-017-12072-5\n

Motion, CL, Cassidy, SL, Cruickshank, PAS, Hunter, RI, Bolton, DR, El Mkami, H, Van Doorslaer, S, Lovett, JE & Smith, GM 2017, ‘The use of composite pulses for improving DEER signal at 94 GHz’ Journal of Magnetic Resonance, vol 278, pp. 122-133. DOI: 10.1016/j.jmr.2017.03.018

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